Pharmacodynamics. Rheopolyglucinum is 10 per cent colloid dextran solution (glucans) with molecular weight 35000-45000 with isotonic sodium chloride solution. Medicine is infused as plasma substituting antishock solution with hemodynamic action. Rheopolyglucinum is favor for increasing plasma volume nearly twofold in comparison with infused volume, inasmuch each gram of glucans causes advance of 20-25 ml of liquid from tissues to bloodstream. As the result of high oncotic pressure Rheopolyglucinum permeates slowly of blood-vascular paries & circulates for long time in bloodstream normalizing hemodynamics by means of liquid flow in concentration gradient from tissues to vessels. As the result of such process arterial pressure is increased & is refraining on high level for long period; tissues hypostasis is reducing. Rheopolyglucinum can be used as deintoxication solution. While it infusing blood flowability is increasing, aggregation of formed elements is reducing. Also Rheopolyglucinum stimulates diuresis increase due to osmotic mechanisms (it filtrates in glomerule, causes high oncotic pressure in primary urine & embarrasses water reabsorbtion in tubule), by that favors (& promotes) toxins & degradations elements of metabolism lead from the body.

Pharmacokinetics. Low molecular fraction of medicine under the nephritic rapids of filtration level exteriorizes from the body with urine till 60-70 per cent during 6-7 hours. High molecular part circulates in blood few days, utilizes by reticuloendothelial system where metabolizes to glucose.

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Pharmacodynamics. Polydextranum is plasma-substituting solution with specific hemodynamics actions. Considering that its molecular weight is nearly the same as albumine, Polydextranum is circulates in blood for long time & detains liquid so it defines its hemodynamic qualities. While it infusing to blood dextran-70 quickly increases arterial pressure during acute blood loss & on a significant time interval keeps it at the raised level.

Pharmacokinetics. The preparation is deduced from an organism mainly with urine (in the first day up to 50%). The insignificant quantity is late in reticuloendothelial system where gradually decays up to glucose.

Pharmacodynamics. Neohaemodesum is capable to connect the toxic products which are taking place in a blood channel and to deduce them through kidneys from an organism.

Pharmacokinetics. At intravenous infusion the effect develops in process of receipt of a preparation in blood and is kept during 3 - 12 hours.

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